human plasma and urine analysis using hplcThe next three application notes in this series on bio-analysis and our new fritless Solid Phase Extraction (SPE) cartridges and plates. Hopefully, by now you have realized that this series began because a recently presented bio-analysis webinar is now on-demand: Addressing the Needs of Bio-analysis with New SPE Technologies – SOL (it requires you to fill out a short form prior to viewing the webinar).

Check out this video presentation (under 3 minutes) on these SPE cartridges on our YouTube channel. These new SPE cartridges are demonstrating much higher levels of reproducibility along with higher levels of extract cleanliness, reduced solvent usage, and increased sensitivity equipment. This is because the cartridges combine the polyethylene frit material and media components into a uniform sorbent bed. Therefore, they do not require frits leading to the aforementioned benefits.

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  • Application Note, LC-MS/MS Method for the Determination of Enalapril and Enalaprilat from Human Plasma, (downloadable PDF) describes a fast separation and a cycle time of 1 minute while maintaining excellent peak shape. Here’s a really interesting bit of information on these two drugs used for the treatment of hypertension. Enlaprilat was developed first but as it is only suitable to be administered intravenously, the prodrug Enalapril was developed. Enalapril can be administered orally and is later metabolized in the liver to form the active component. Our HPLC system (Thermo Scientific Accela 600) and one of oursilica-based HPLC columns (Thermo Scientific Hypersil GOLD column) was used in this experiment.

Also, there will be one last blog post in this series with the final three application notes. Do let us know if you are looking for applications not mentioned in this series so far in the Comments box below. Our application chemists will be pleased to consider your request.