One of our key extraction solutions that has become very popular is our Accelerated Solvent Extraction (ASE) for the extraction of solid and semisolid sample matrices using common solvents at elevated temperatures and pressures. The great benefit to using this technique is that extractions that normally take hours can be done in minutes!
Here we present a customer question and answer from one of our experts on using ASE for sample extraction in transdermal patches!
I am interested in doing drug assays on transdermal patches where the drug is dissolved in acrylic adhesive on the patch. Can the patches be cut to fit into an extraction cell?
Yes, you can cut the patches to fit them into the extraction cells. We have also done a lot of work with transdermal patches using the ASE technique. Application note 327, Extraction of Nitroglycerin from Transdermal Patches by Accelerated Solvent Extraction (ASE), (downloadable PDF) describes our work with a transdermal patch and describes how the total sample preparation time using the ASE technique was only 30 min per sample versus the 2 hours required by the sonication procedure (the standard extraction procedure for this type of a sample). In addition, you can avoid the use of solvents that are expensive, toxic, and require costly disposal.
Here is a short video (4 min 26 s) on our ASE system.
Let us know of your analytical challenges in pharma in the Comments box; we would be very pleased to feature it in a blog post with a response from our experts!