IC analysis of pharma anions and cationsThis is the first blog post in the series of posts on the advantages of the newly introduced Capillary Ion chromatography (IC) over IC in water analysis, pharmaceutical applications, and food testing market. Our application lab in Sunnyvale has been very busy updating some of the existing IC methods on capillary IC and we recently released a number of these application notes for a number of different markets.

The key benefit of Capillary IC is that it helps chemists save time, labor, and reduce operating cost, while increasing the productivity and reproducibility of ion analysis. How? Since the system operates at such low flow rates (~10 µl/min), it is practical to operate a Capillary IC 24/7, so the system is ready to run samples at any time! Also, the Eluent Generator module (EG) is able to produce eluent automatically from deionized water for up to 18 months under continuous operation, making gradient separations as easy as isocratic.

Here are two recently released application notes for pharmaceutical analysis using Capillary IC.

Application Implementation of a Walk-Up High-Pressure Capillary Ion Chromatograph for the Fast Separation of Pharmaceutically Relevant Inorganic Anions and Cations discusses the determination of inorganic anions and cations in two different drugs using a capillary IC system. The note highlights how the reagent-free capillary systems reduce eluent preparation, system start up time, and equilibration time, and require less frequent calibrations.

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Application Quantitative Determination of Bisphosphonate Pharmaceuticals and Excipients by Capillary Ion Chromatography Mass Spectrometry describes a quantitative method for the direct analysis of bisphosphonates and excipients in prescription tablets using capillary IC with conductivity and mass spectrometric detection.

You might be interested in reading up on our newly released Capillary Fast IC columns that facilitate separations up to 4 times faster than conventional columns.

Let us know if you are using capillary IC in your analytical work in the comments box below. Also, don’t forget to add any questions or comments you might have regarding this application. Our experts will be pleased to answer your questions.