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2558-2

Column Temperature Control in Peptide Mapping

Separation efficiency and peak capacity are important to analyze complex samples (e.g., peptide mapping). They depend on column plate number, system performance, and column temperature. In this article a new binary biocompatible UHPLC system is described that provides two column thermostatting modes, namely forced-air and still-air. For complex peptide mixtures of monoclonal antibody digests, still-air mode generates higher peak capacity compared to forced-air. Interestingly, the capacity gain is more evident at high temperature.

Technique: Liquid Chromatography Resource Type: Journal Article
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