Worldwide, researchers are searching for ways to boost the immune system’s ability to fight cancer; one such way is by developing novel therapeutics within the pharmaceutical/biopharmaceutical industry. Technologies such as liquid chromatography and mass spectrometry (LC-MS) can provide insights into drug structure and activity at the cellular level, providing greater confidence in drug discovery, quality, and purity. Recent developments in LC-MS hardware, software, columns, and sample prep offer a new paradigm in drug discovery, and LC-MS techniques are being applied to unravel complex cascades of protein interactions that underlie disease states. Peptide mapping is one way to measure critical quality attributes (CQA) required for the characterization of biotherapeutic proteins.
SMART Sample Preparation
Characterize and quantitate proteins more quickly, easily, and reproducibly than ever before with simple sample preparation kits. Offering a significant improvement over in-solution protein digestion, Thermo Scientific™ SMART™ Digest Kits can typically digest monoclonal antibodies in less than an hour and are compatible with automation.
Thermo Scientific™ MAbPac™ columns complement each other to give you a complete solution for RP, HIC, SEC, and IEX/charge variant analysis for intact proteins, mAb separations, and CQA characterization.
New: Thermo Scientific™ ProPac™ Elite WCX columns for weak cation exchange (WCX) liquid chromatography.
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Optimize Your Peptide Map with the Sensitivity and Speed of HRAM Mass Spectrometry
Thermo Scientific™ EASY-Spray™ columns are integrated, temperature-controlled units that require only a single, simple connection to MS detectors. The column/emitter design with zero-dead-volume fittings offers highly stable performance, better separations, and class-leading column-to-column reproducibility. Also available in a capillary flow format for high-throughput screening.
There’s a Lot More That Goes into Our Products Than Just Samples
Designed and tested for chromatography applications, Thermo Scientific™ WebSeal™ products are compatible with today’s autosamplers and prep stations for efficient, high-throughput sample handling—featuring an inert surface helping to ensure the integrity of your samples and validity of your results.
Separate Your Science from the Status Quo with Vanquish UHPLC Technology
Our latest innovation in UHPLC is the Thermo Scientific™ Vanquish™ Duo system. This unique platform is designed with two flow paths for three different workflows—dual LC; tandem LC or LC-MS; and inverse gradient. The system’s exceptional performance and ease of use helps reduce cost per sample and enhance your productivity without needing additional bench space.
Characterize More in Less Time with the Most Sensitive Mass Spec Instrument on the Market
Whether you’re working with HPLC, MS, or a combination of both, the Thermo Scientific™ Q Exactive™ HF-X Hybrid Quadrupole-Orbitrap™ Mass Spectrometer is up to the challenge. This instrument can help you identify improved diagnostics and more effective treatments to boost the immune system’s fight against cancer by offering more reliable and accurate solutions to discover and characterize biomolecules.