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TMT10 TAILS Workflow
TMT10-TAILS-Workflow-for-Identification-and-Quantitation-of-the-N-terminome-by-Terminal-Amino-Isotope-Labeling-of-Substrates

TMT10 TAILS Workflow for Identification and Quantitation of the N-terminome by Terminal Amino Isotope Labeling of Substrates

The N-terminal amino acid and its modification are known to have a major impact on protein stability and half-life. Proteolysis generates new protein N-termini, known as neo N-termini, and is an essential post-translational modification significantly impacting the fate of a protein and those it interacts with. Consequently, proteases and their substrates are an increasingly important domain of study in proteomics and drug development.

Technique: LC-MS Resource Type: Poster
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